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It is worth noting that DMF neither affected the antitumor activity in C26, HCT116, MKN45, and MIA PaCa-2 cancer cell lines nor exacerbated the potential effects (e.g., body weight loss or bone marrow suppression) in C26-bearing mice (Miyagi et al., 2019)

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The clinician takes a thorough medical history, asks about current symptoms such as pelvic pain, menstrual changes, fertility concerns, or signs of systemic inflammation, and notes prior treatments and medication use

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