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Huang, M
Polyphenols also associated with an increase in glutathione levels
Combinative treatment of -elemene and cetuximab could induce ferroptosis of KRAS-mutant colorectal cancer cells (CRC) by iron-dependent ROS accumulation, GSH depletion, lipid peroxidation, upregulation of HO-1 and transferrin, and downregulation of negative regulatory proteins for ferroptosis (GPX4, SLC7A11, FTH1, glutaminase, and SLC40A1), thus inhibiting tumor growth and lymph node metastases in vivo (Chen et al., 2020b)
It offers a versatile and user-friendly way of accessing glutathione as oral forms such as tablets, capsules and powders, providing consumers with a non-invasive and convenient option
