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Cell lines were routinely tested for the presence of mycoplasma

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Nat Chem Biol

In the prefrontal cortex of 3xTg mice, elevated spontaneous excitatory postsynaptic currents and firing rates have been observed in pyramidal neurons (Choudhury et al., 2023), and additional studies indicate increased excitatory and inhibitory inputs to layer 2/3 pyramidal neurons, potentially linked to altered social behavior (Bories et al., 2012)

Subgroup analyses found that curcumins antidepressant effects were duration-dependent: interventions over 8 weeks yielded significant benefits (SMD = 2.58, 95% CI: 4.54 to 0.61), whereas shorter courses (8 weeks) did not (SMD = 1.21, 95% CI: 2.59 to 0.17)