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MD simulation supports that the ZIL was concentrated near the surface of cellsZIL molecules, especially their carboxylates, electrostatically interact with the cell membrane, and consequently, ZIL is concentrated ~3 times more densely on the polar surface of the cell membrane than in the bulk state, even at 37 C (Fig

The analytical data was found to be in agreement with the previous literature 46

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[19] [20] These trials, however, were primarily designed to assess glycaemic efficacy and cardiovascular outcomes, and their duration (typically 12 years) may be insufficient to detect rare malignancies with long latency periods