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The protein structure of GLP-1 receptor agonists is fragile

Standard oral dosing is 500 mcg once daily on an empty stomach

29 In terms of the nervous system, GLP-1 receptor (GLP-1R) expression is enriched in central nervous system (CNS) regions, including the hypothalamus, which regulates appetite, and the brainstem, which primarily secretes brain-derived GLP-1, as well as in the peripheral vagus nerve

For patients with type 2 diabetes who start above an HbA1c of 8%, that level of reduction can translate to a clinically significant lower risk of microvascular complications over time

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