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Jacqueline Maya, M.D., from Massachusetts General Hospital-Mass General Brigham in Boston, and colleagues conducted a retrospective cohort study of 149,790 singleton pregnancies delivered between June 1, 2016, and March 31, 2025, to compare weight gain and pregnancy outcomes with and without exposure to GLP-1 RAs before or during early pregnancy

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Fourth, the robustness of our results was evaluated via comprehensive sensitivity analyses

Monami et al

Common effects of sudden discontinuation include: Return of appetite : The appetite-suppressing effects diminish, often leading to increased hunger and food cravings Blood glucose elevation : For those with type 2 diabetes, blood sugar levels typically rise as the glucose-lowering effects wear off Weight regain : Many patients experience weight increase, sometimes rapidly, as metabolic changes reverse Gastrointestinal changes : The slowed digestion that Ozempic provided normalises, which some patients notice as altered bowel habits It is important to understand that stopping Ozempic suddenly does not typically cause dangerous withdrawal symptoms in the traditional sense