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J Biochem Mol Toxicol 37:e23323

Heat stress reduces membrane stability by denaturing membrane-bound proteins and deactivating essential enzymes, resulting in increased permeability and loss of membrane integrity, disrupting ion flux, electrolyte leakage, changes in relative water content, the accumulation of harmful compounds, and the disruption of cellular homeostasis, thereby decreasing cell viability (Nijabat et al