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Before starting compounded semaglutide with Vitamin B12, it is important to understand that this is not an FDA-approved combination

In addition to renal outcomes, SGLT2 inhibitors also contribute to modest weight loss and blood pressure reduction

In a Phase 3 study called the Step-Up trial, people taking the 7.2 mg dose lost almost 19% of their body weight on average

PMCID: PMC9624240 DOI: 10.1161/CIRCULATIONAHA.122.061732 Packer M (2023): SGLT2 inhibitors: role in protective reprogramming of cardiac nutrient transport and metabolism

The combination of mechanical unloading and direct cartilage protection is a powerful one-two punch that has a lot of orthopedic surgeons paying very close attention right now