4 The deposition of ectopic fat caused by obesity can lead to biological dysfunction of skeletal muscles, including inflammation, insulin resistance (IR) and oxidative stress
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meaningful appetite reduction often emerges during the first week, while measurable weight loss generally becomes apparent from weeks four to eight onwards
"New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle"
This mechanism suppresses RAGE/NF-B signaling, thereby reducing inflammation, oxidative stress, and lung damage, ultimately improving survival (Zhang et al., 2021)