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Tumours were allowed to grow to a volume of 50 mm 3 and mice were randomized into control ( n =5) and C1-27 ( n =3) treatment groups

In DKD, TEC pyroptosis is primarily governed by the NLRP3 inflammasome signaling axis (165, 166)

PMCID: PMC7019700

For ACF, the existing strategies mainly include chemoprevention (such as the use of drugs like aspirin and celecoxib), dietary modification (increasing fiber intake and reducing the consumption of red meat and fat), as well as preventing the occurrence and development of colorectal cancer through endoscopic monitoring and the resection of high-risk lesions 49,50

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