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Lets look at what the research actually says

Oral supplements are far less expensive per dose but have lower and more variable absorption

Individuals who maintain exercise habits and dietary modifications during treatment tend to regain less, though some regain appears to be driven by hormonal and neurological adaptation independent of lifestyle choices

Negative staining of phospholipids and their structural modification by surface-active agents as observed in the electron microscope

This review has deliberately distinguished failed biology from failed pharmacology, emphasizing that genuine on-target toxicity, repeated lack of efficacy in well-designed human studies, or insurmountable technical barriers justify abandonment