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NKCC1 is also known to regulate glioma cell volume changes by increasing [Cl ] i , which results in Cl efflux upon GABA binding and cell shrinkage to promote glioma cell proliferation, migration, and invasion of surrounding parenchyma (Table 1

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doi: 10.1080/14728214.2018.1527901

For example, the MC4R in humans has a well-known role in appetite regulation, as shown by studies in MC4R deficient study volunteers, showing increased appetite for high-fat foods and consequently increased intake of calories [21]