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Patients with T2D not adequately controlled on therapy with metformin and insulin glargine as baseline therapy received either tirzepatide at the doses used in the SURPASS trials or placebo during the 40-week study setting

Implications for Clinical Practice These findings suggest that GLP-1 receptor agonists are not only safe from a pancreatitis risk perspective but may also confer protective effects in patients who develop acute pancreatitis

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It can be difficult to tell the difference between expected appetite changes and concerning behaviors with GLP-1 use

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