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Regarding intracellular roGFP2-based structure-function analysis of glutaredoxins, we now showed that the GSSG-dependent oxidation of the fused glutaredoxin moiety (and not the glutathionylation of the roGFP2 moiety) is rate-limiting unless saturating GSSG concentrations are present
However, these effects were only demonstrated in people who were overweight or obese
Nat Med (2014) 20(1):628
This means operational manufacturing that integrates new developments in areas like peptide synthesis and fill/finish
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