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Some people are unable to tolerate the drugs because of their side effects, particularly severe nausea and diarrheaa 2021 study showed 4.5 percent of people taking semaglutide discontinued the drug because of gastrointestinal issues
Semaglutide acts primarily on GLP-1 receptors, while Tirzepatide is a dual GIP and GLP-1 receptor agonist, which may offer enhanced effects for some people
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