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Research also indicates that people who take these medications are at increased risk of gastrointestinal events, such as pancreatitis, bowel obstruction, or gastroparesis
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However, it's important to note that this combination is considered off-label use , and the Zepbound prescribing information specifically states it has not been studied with other weight loss products
In the 28-week, phase three randomized control trial (RCT) DURATION-8, dual therapy with an SGLT2 inhibitor (dapagliflozin) and a GLP-1RA (once-weekly exenatide) was shown to reduce HbA1c by 0.4% more than either agent alone, in patients with a starting HbA1c of between 8-12% 50 , illustrating that the glycemic response to dual therapy is less than additive 50
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