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GLP-1 drugs slow gastric emptying and reduce appetite, which can lead to lower calorie intake and fluid lossboth factors that naturally lower blood pressure
Tirzepatide injections (at $289/mo month-to-month, or from $249/mo on the 6-month plan) bind both GLP-1 and GIP receptors, showing slightly greater weight reduction in head-to-head trialsapproximately 2-4% additional lossthough individual response varies significantly based on genetic factors
Patients with chronic kidney disease represent another important consideration, as traditional diabetes medications often require dose adjustments or become contraindicated as kidney function declines
doi: 10.1073/pnas.94.24.13215 88 ZhuX.CaoY.VoodgK.SteinerD
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