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Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58)

High doses dont necessarily speed up healing and may waste product or desensitize receptors over time

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The full-length parent (43 residues, ~4,963 Da) has been investigated under multiple INDs (RGN-259 / RGN-352 by RegeneRx Biopharmaceuticals) for dry-eye disease, neurotrauma, and wound healing