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Dose-response and pharmacokinetics Research to characterize absorption, distribution, metabolism, and excretion in reproductive organs, as well as safe dose ranges and optimal delivery routes for focused targeting of gonadal tissue without systemic exposure

Abraham A, Kattoor AJ, Saldeen T, Mehta JL

Effective preventative measures for patients at risk for cholelithiasis include a slower rate of weight loss, increasing/including some dietary fat in the diet (assuming the patient has been on a very low-calorie diet containing little or no fat), or administration of ursodeoxycholic acid