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Why Tirzepatide Causes Nausea and Stomach Changes Tirzepatide works by mimicking two natural hormonesglucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)that regulate blood sugar and appetite

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For users meaningfully lighter or cardiovascularly more responsive than the trial cohort low BMI, sub-160 lb, lean/recomposition-focused, older, or dose-sensitive the entry point drops to 0.3 mg