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Early studies demonstrated that Ipamorelin effectively activated the growth hormone secretagogue receptor (GHS-R1a), resulting in increased growth hormone secretion through ghrelin-related signaling mechanisms

doi:10.1038/s41467-018-03941-2 18

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In dispersed rat pituitary cell cultures, the system used to characterize both CJC-1295 No DAC and Ipamorelin, co-administration of GHRH and GHRP-6 produced GH release significantly exceeding the sum of individual responses

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