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By week 12, patients on an appropriate dose often report 8 to 15 pounds of weight loss and sustained appetite control that feels effortless compared to diet-only efforts

Weeks 25-28: Retatrutide 8-12 mg weekly + Cagrilintide 1.7 mg weekly

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This concern is particularly relevant with aggressive caloric deficits, and cagrilintide's appetite-suppressing effects can create substantial caloric deficits