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Similar to K cells, L cells also express the Galinin receptor, GAL 1 , and its activation via Galinin treatment or GAL 1 agonist (M617) treatment prevents the accumulation of cyclic adenosine monophosphate (cAMP) in L cells within primary duodenal cultures in response to the adenylyl cyclase activator, forskolin and inhibits GLP-1 secretion from primary duodenal and ileal cultures (Psichas et al., 2016)
The dosing conditions, schedule and washout period in both studies ensured there was no effect of food or drugdrug interaction between the two drugs evaluated in each study
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All duplicates presented in this work were done using the same laser/power, exposure time / Gain and same microscope/camera alignment
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