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Despite decades of research and numerous clinical trials, not a single disease-modifying therapy has been approved for osteoarthritis
European Journal of Nutrition , 54(2), 251263.
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High ROS levels induce reversible oxidative PTMs on critical thiol residues of ETC proteins (for example S-glutathionylation or S-nitrosylation of Complex I subunits), impairing electron transport efficiency and increasing electron leakage that further amplifies ROS production and lowers m (58)
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