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Selective MC4R agonists like setmelanotide avoid pigmentation by binding exclusively to MC4R, but theyre significantly more expensive and less widely available for research purposes

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A 2024 paper in Physiology & Behavior characterised that ipamorelin and the related GHSR-1a agonist anamorelin inhibited cisplatin-induced weight loss in ferrets, framing one route by which the GHSR-1a agonist class engages cachexia research (PMID 39043357)

This can make it easier to maintain a calorie deficit

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