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Similarly, a post-hoc analysis of SURPASS-1, enrolling 478 patients with T2D, found that all doses of tirzepatide as monotherapy increased insulin sensitivity compared to placebo, as suggested by the decreases in HOMA2-IR by 923% (vs +14.7% with placebo) and fasting insulin levels by 212% (vs +15%) and the increase in adiponectin by 1623% (vs 0.2%) and IGFBP-2 by 3870% (vs +4.1%) at 40 weeks [76]
Antioxidant Protection: As a powerful antioxidant, glutathione protects skin cells from UV exposure and free radical damage
These agents may need to be used for longer durations or discontinued using tailored strategies to maintain effective weight loss
Do not neglect these fundamentals while focusing on the peptide
They still benefit from cool storage but are far more forgiving during brief temperature excursions
