Given these emerging connections and in partnership with Reuters , we wanted to better understand the real-world overlap between people using GLP-1 RA medications and those diagnosed with PCOS
But the real story is the metabolic repair underneath it
It acts as a dual agonist at amylin receptors (AMY1R, AMY2R, AMY3R, formed by calcitonin receptor heterodimerized with RAMP1-3) and calcitonin receptors, with structural modifications (e.g., N-terminal fatty acid acylation, proline substitutions) preventing fibril formation, enhancing stability, and enabling once-weekly dosing via albumin binding for prolonged circulation
10.1016/j.molmet.2024.101978 117 MaS.WangM.WuY.MengD.ZhangB.ZhuH.et al (2025)
For a deeper overview, see our Cagrilintide research guide