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These are two brainstem regions critical for controlling food intake and meal termination

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A 1mg dose clears predictably within 68 hour half-life parameters, but a 5mg dose may exhibit half-life extension to 911 hours as the kidneys process the larger peptide load

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doi: 10.1016/j.cell.2014.03.060 214 OmenettiAChoiSMichelottiGDiehlAM