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In myocardial ischemia-reperfusion injury, ferroptosis has been implicated not only in cardiomyocyte loss and post-ischemic remodeling but also in cell-to-cell propagation of injury along aligned myofibers
In a study investigating how alterations in Mn-SOD (SOD2) affect the mitochondrial ROS balance (e.g., O 2 - ) and tumor cell adaptation, ROS levels and survival/adaptation-related indicators (ROS assays, protein analyses, and cell viability tests) were evaluated in HGSOC cells following modulation of Mn-SOD expression
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The symptoms range from mild irritation and pain to haemorrhage and possibly perforation
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