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The body regulates B12 absorption through intrinsic factor, a protein produced in the stomach that binds to B12 and facilitates its uptake in the terminal ileum

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[16] The European Food Safety Authority (EFSA) refers to the collective set of information as "dietary reference values", with population reference intake (PRI) instead of RDA, and average requirement instead of EAR

Because B12 is water-soluble, the NIH Office of Dietary Supplements notes that no tolerable upper intake level has been established excess B12 is excreted by the body rather than accumulating to toxic levels

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