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Functionally, the main compounds (emodin, rhein, baicalin, and chrysin) from Chaiqin chengqi decoction diminished pancreatic acinar cell necrosis and systemic inflammation by inhibiting the TLR4/NLRP3 pathway (Wen et al., 2020)

To differentiate between the potential involvement of these two consequences in H 2 O 2 -induced sensitization to TNF hepatotoxicity, we first exposed HepG2 cells to (BSO), a potent inhibitor of gamma-glutamylcysteine synthetase, the rate-limiting enzyme in the glutathione synthesis pathway (Fig

This may help explain why it is little used by health professionals