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While these compounds principally target GPX4, they might also exert effects on TXNRD1 in A549 and H1975 cancer cells [217]

In this specific cycle: 1 Hydrogen peroxide, a free radical and reactive oxygen species, is converted into water (harmless), and oxygen 2 Two molecules of reduced Glutathione [GSH (the active antioxidant form of glutathione)] are used by the Glutathione peroxidase enzyme to neutralize one molecule of hydrogen peroxide 3 NADPH is used by glutathione reductase enzyme to reduce ("recycle") glutathione disulfide back into usable reduced glutathione Key players: Selenium: Essential for the enzyme that initiates the breakdown of hydrogen peroxide Riboflavin (FAD - coenzyme form of riboflavin): essential for the enzyme that restores the oxidized Glutathione back to its more useful state

Ohba T, Domoto S, Tanaka M, Nakamura S, Shimazawa M, Hara H

Lands et al., 1999

An identifiable cause can be found in 85% of infertile couples, whereas the remaining 15% are classified as unexplained infertility (42, 44)