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"The discovery and development of liraglutide and semaglutide." Frontiers in Endocrinology , 10, 155
The intrinsic pathway can be triggered either as a result of mPTP opening, or activation of the proapoptotic proteins of the B-cell lymphoma 2 (Bcl-2) family, Bax and Bak [192] after the removal of the block of antiapoptotic proteins Bcl-2 and Bcl-XL [193]
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however, patient satisfaction with current treatment modalities unfortunately is not as successful as wed like
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