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Patient-specific risk factors include: Personal or family history of nephrolithiasis : Individuals with prior kidney stones have a recurrence rate of approximately 50% within 510 years, making this the strongest predictor of future stone formation

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14 , e00578 (2023)

Several studies have indicated that the presence of S aggregates in the gut can spread out to the brain via the vagus nerve ( S has a high binding affinity for pre-synaptic vesicles and its accumulation in pre-synaptic terminals is a sign of synaptopathy