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Different concentrations of ZFPG NPs (final concentration 0 g mL 1 , 50 g mL 1 , 100 g mL 1 , 150 g mL 1 , and 200 g mL 1 ) were incubated with glucose solution (final concentration 1 mg mL 1 ) for 3 h, and then the pH value of the solution was detected by pH meter

Known as Sakel's technique, insulin coma therapy was a common treatment for schizophrenia until the late 1950s when it fell out of fashion (Marks 2018

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The main causes of this disease include overnutrition and higher levels of glucose and free fatty acids in the blood that stimulate insulin secretion (46)

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