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The ability of AMG 133 to lower body weight and improve metabolic markers in male obese mice and cynomolgus monkeys is reported by researchers, who also confirm the GIP receptor antagonist and GLP- 1 receptor agonist activities in cell-based systems

Low-dose lithium , promoted for brain aging after a 2025 Harvard study showed brain lithium is depleted early in Alzheimers and that lithium orotate reversed pathology in mice, has only mixed human trial evidence and works by dampening neuronal firing, so I do not recommend it for a healthy brain

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