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Methionine is then converted into S-adenosylmethionine, which donates methyl groups in reactions catalyzed by methyltransferases, including DNA methylation, producing S-adenosylhomocysteine that is converted back into homocysteine
Preparation of hypothalamic samples for LC-MS/MS analysis For the proteomic analysis by LC-MS/MS, hypothalamic samples were dissected, immediately frozen in liquid nitrogen, and stored at 80 C until used
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The activated Trem2 signal in stage 1 DAM facilitates transition to stage 2 DAM, which is characterized by an upregulation of lysosomal, phagocytic, and lipid metabolism pathway-related genes including cst7 and itgax
The second affects the cystathionine-beta-synthase (CBS) enzyme responsible for removing excess sulfur-containing amino acids from the system and converting homocysteine into cystathionine
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