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Therefore, the simple explanation as to why individuals in these studies lose so much lean mass is due to (1) the lack of exercise (in particular resistance exercise) and (2) the chronic negative energy balance

ROS act as key secondary messengers in cells, influencing various cellular functions, including regulating gene expression, controlling cell survival, and modulating intracellular signaling networks (35)

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Moderate but significant apoptosis was observed in HUVECs expressing kdNDUFS8, as indicated by an increased ratio of TUNEL-positive nuclei (Fig