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New horizons of synthetic lethality in cancer: current development and future perspectives
Ethics statement The animal studys experimental procedures involving animals were conducted in accordance with the Institutional Animal Care Guidelines of Shanghai University of Medicine and Health Sciences, China, and were approved by the Administration Committee of Experimental Animals, Shanghai, China
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It also has hydrogen bonds to three main chain atoms (Val 53 N and O, Ser 71 N) and three hydrogen bonds to amino acid side chain atoms (Tyr 10 OH, Trp 41 NE2, Ser 71 OG)
A genome-wide association study demonstrated that the serine/threonine kinase encoding - ATM gene (ataxia telangiectasia mutated) has potential involvement in the mechanism of enzymes responsible for response to metformin (Zhou et al., 2011)
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