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In the future, more experimental studies and high-quality large-sample clinical trials are still needed to explore the effects of spicy components on mental disorder diseases through the microbiota-brain-gut axis
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Starting with low GLP-1 doses while continuing established metformin therapy minimizes these effects, as the body adapts to the GLP-1 signal over weeks
In contrast, renal arteries from Glp1r VSM/ mice exhibited only minor proteomic alterations after semaglutide treatment (9 proteins in total), none of which overlapped with the changes observed in Glp1r VSM+/+ mice (Figure 6D)
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