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Weight Loss: The Data At this time, there arent any published head-to-head obesity trials directly comparing oral semaglutide to orforglipron, says Maria Teresa Anton, MD, a board-certified internal medicine physician who specializes in endocrinology, diabetes, and metabolism with Pritikin Longevity Center in Miami

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The biology of GLP-1 cells has garnered renewed interest due to the current approval of GLP-1 analogs for the pharmacological treatment of type-2 diabetes and obesity 13,14,15

His overarching counsel, though, treats the condition itself as the constant: "obesity is a chronic, relapsing disease analogous to hypertension," typically demanding ongoing treatment to hold the gains