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A successful synthesis of an isatinimino acridinedione moiety with impactful anti-inflammatory responses, achieved through the inhibition of the in vivo NF-B and COX-2 signal transduction pathways, was reported by Periyasami et al
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No heating should be required at typical use concentrations
[PMID: 15131110] PubMed record related to this compound for laboratory literature review
This structural observation indicates that HGF I is the activating ligand that promotes c-MET dimerization and activation, whereas HGF II plays an auxiliary role that strengthens the interaction between HGF I and c-MET II
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