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The approved dosing regimen begins at 0.25 mg once weekly for four weeks (an initiation dose to improve tolerability), then increases to 0.5 mg once weekly, with further increases to 1 mg or 2 mg if needed for glycaemic control
His reduction in LV mass carries clinical significance as increased LV mass has been associated with a heightened risk for heart failure hospitalizations and cardiovascular death in heart failure with preserved ejection fraction [15]
Retatrutide is the developmental designation for an investigational compound owned by Eli Lilly and Company
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