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they are not evidence about cagrilintide by itself, and it is misleading to compare them to retatrutide monotherapy

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Preclinical studies demonstrate that DSIP can alter pain threshold responses, with observed effects that are not reversed by opioid receptor antagonists such as naloxone, suggesting involvement of non-opioid or indirect neuromodulatory pathways [7]

Funding was provided by the Medical University of Biaystok, Poland (Grant No.: B.SUB.25.250)