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Because SDH is the only enzyme that participates in both the TCA cycle and the ETC, we speculated that the ETC might be compromised in Gclc -deficient FoB, thus explaining the inhibition of SDH and the accumulation of succinate

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40 Indeed, patients at later stages of HF may respond differently to therapy that improves outcomes in less severe disease states

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Second, establish baseline measurements for all relevant biomarkers before introducing either compound