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Abdulghani AA, et al
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After a single injection, mean plasma IGF-1 concentrations increased 1.5 to 3-fold for 9 to 11 days
Doses should be adjusted based on kidney function
These released exosomes can then modulate immune response in other cells through a payload of inflammatory cytokines, like TNF-alpha, or through microRNA s that decrease inflammation.[ref] Mast cell release of exosomes has been shown to increase the formation of collagen in fibroblasts, which can lead to fibrosis (including pulmonary fibrosis, IPF)
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