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Heres the one-sentence summary: IGF-1 DES (des(1-3)IGF-1) is a truncated analog of insulin-like growth factor-1 thats been modified to eliminate its first three amino acids, making it roughly 10 times more potent than regular IGF-1 at the tissue level with a drastically shorter half-life of about 20-30 minutes

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Interestingly, epileptogenesis secondary to BBB injury largely involves the activation of inflammatory responses and reactive astrogliosis, attributes observed in the GBM microenvironment

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