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At the same time, escalating drug costs (total spending up 10.2% in 2024, with the pharmacy trend projected at 11.4% for 2025 ( [15] )) driven significantly by GLP-1 adoption mean that mastering PBM negotiation has never been more critical

This mechanism explains the core logic of its weight loss effect - by reducing energy intake, forcing the body to use fat reserves for energy supply

"My job is to keep people in the lane of reasonable weight loss," Snyder said

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Over time, as the body adjusts to the medication, the intensity of nausea usually decreases