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Surrogate endpoints are measurable markers like blood pressure and cholesterol that correlate with disease outcomes but dont directly measure events

Konstantin Vasyukevich, M.D.: We do not yet have strong evidence that GLP-1 medications directly cause facial bone loss, but rapid weight loss can reduce the fat, muscle and soft-tissue support that gives the face its structure

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Long-term follow-up of the TRED-HF trial: Implications for therapy in patients with dilated cardiomyopathy and heart failure remission

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