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GLP-1 drugs were initially developed for controlling blood sugar (glucose) levels in people with Type 2 diabetes
Although semaglutide and tirzepatide have transformed the treatment of obesity and diabetes, they are not miracle drugs that work independently of healthy habits
Side effects may include local injection site reactions, gastrointestinal disturbances, hypersensitivity reactions, hemolytic anemia in G6PD-deficient patients, and kidney stone formation in susceptible individuals
The question of tolerability and adherence ultimately led to investigating oral forms of GLP-1 RAs
These are important because providers adjust medication dosages over time to help patients get the best results while minimizing the risk of side effects
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